node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCB63455.1 | nnrE | HYPMC_0218 | HYPMC_1293 | Putative ATP-independent RNA helicase, DEAD/DEAH-box family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DEAD box helicase family. | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] | 0.929 |
CCB63455.1 | rph | HYPMC_0218 | HYPMC_4703 | Putative ATP-independent RNA helicase, DEAD/DEAH-box family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DEAD box helicase family. | Ribonuclease PH (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.705 |
CCB63455.1 | rppH | HYPMC_0218 | HYPMC_4890 | Putative ATP-independent RNA helicase, DEAD/DEAH-box family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DEAD box helicase family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.649 |
CCB63455.1 | rppH-2 | HYPMC_0218 | HYPMC_4891 | Putative ATP-independent RNA helicase, DEAD/DEAH-box family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DEAD box helicase family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.649 |
CCB64102.1 | nnrE | HYPMC_0869 | HYPMC_1293 | DEAD/DEAH box helicase domain protein; Belongs to the DEAD box helicase family. | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] | 0.929 |
CCB64102.1 | rph | HYPMC_0869 | HYPMC_4703 | DEAD/DEAH box helicase domain protein; Belongs to the DEAD box helicase family. | Ribonuclease PH (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.705 |
CCB64102.1 | rppH | HYPMC_0869 | HYPMC_4890 | DEAD/DEAH box helicase domain protein; Belongs to the DEAD box helicase family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.649 |
CCB64102.1 | rppH-2 | HYPMC_0869 | HYPMC_4891 | DEAD/DEAH box helicase domain protein; Belongs to the DEAD box helicase family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.649 |
CCB68096.1 | CCB68097.1 | HYPMC_4888 | HYPMC_4889 | Peptidase M23. | Putative periplasmic carboxyl-terminal processing protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase S41A family. | 0.924 |
CCB68096.1 | rppH | HYPMC_4888 | HYPMC_4890 | Peptidase M23. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.594 |
CCB68096.1 | rppH-2 | HYPMC_4888 | HYPMC_4891 | Peptidase M23. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.429 |
CCB68097.1 | CCB68096.1 | HYPMC_4889 | HYPMC_4888 | Putative periplasmic carboxyl-terminal processing protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase S41A family. | Peptidase M23. | 0.924 |
CCB68097.1 | rppH | HYPMC_4889 | HYPMC_4890 | Putative periplasmic carboxyl-terminal processing protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase S41A family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.673 |
CCB68097.1 | rppH-2 | HYPMC_4889 | HYPMC_4891 | Putative periplasmic carboxyl-terminal processing protease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase S41A family. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.529 |
RNR | rph | HYPMC_1125 | HYPMC_4703 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Ribonuclease PH (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.994 |
RNR | rppH | HYPMC_1125 | HYPMC_4890 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.786 |
RNR | rppH-2 | HYPMC_1125 | HYPMC_4891 | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.786 |
dapF | rppH | HYPMC_4623 | HYPMC_4890 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.799 |
dapF | rppH-2 | HYPMC_4623 | HYPMC_4891 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | (di)nucleoside polyphosphate hydrolase (Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.805 |
nnrE | CCB63455.1 | HYPMC_1293 | HYPMC_0218 | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] | Putative ATP-independent RNA helicase, DEAD/DEAH-box family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DEAD box helicase family. | 0.929 |