| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FP2_12050 | FP2_25060 | FP2_12050 | FP2_25060 | ATPases of the AAA+ class. | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.819 |
| FP2_12050 | dnaJ | FP2_12050 | FP2_12310 | ATPases of the AAA+ class. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.819 |
| FP2_12050 | dnaK | FP2_12050 | FP2_12320 | ATPases of the AAA+ class. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.982 |
| FP2_12050 | dnaK-2 | FP2_12050 | FP2_26120 | ATPases of the AAA+ class. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.982 |
| FP2_12050 | groL | FP2_12050 | FP2_04990 | ATPases of the AAA+ class. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.760 |
| FP2_12050 | groS | FP2_12050 | FP2_04980 | ATPases of the AAA+ class. | Co-chaperonin GroES (HSP10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.618 |
| FP2_12050 | grpE | FP2_12050 | FP2_12330 | ATPases of the AAA+ class. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.770 |
| FP2_12050 | htpG | FP2_12050 | FP2_18560 | ATPases of the AAA+ class. | Molecular chaperone, HSP90 family; Molecular chaperone. Has ATPase activity. | 0.957 |
| FP2_12050 | lon | FP2_12050 | FP2_06390 | ATPases of the AAA+ class. | ATP-dependent proteinase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.625 |
| FP2_25060 | FP2_12050 | FP2_25060 | FP2_12050 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATPases of the AAA+ class. | 0.819 |
| FP2_25060 | dnaK | FP2_25060 | FP2_12320 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.992 |
| FP2_25060 | dnaK-2 | FP2_25060 | FP2_26120 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.992 |
| FP2_25060 | groL | FP2_25060 | FP2_04990 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.864 |
| FP2_25060 | groS | FP2_25060 | FP2_04980 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Co-chaperonin GroES (HSP10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.664 |
| FP2_25060 | grpE | FP2_25060 | FP2_12330 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.925 |
| FP2_25060 | htpG | FP2_25060 | FP2_18560 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Molecular chaperone, HSP90 family; Molecular chaperone. Has ATPase activity. | 0.974 |
| FP2_25060 | lon | FP2_25060 | FP2_06390 | DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATP-dependent proteinase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.546 |
| dnaJ | FP2_12050 | FP2_12310 | FP2_12050 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATPases of the AAA+ class. | 0.819 |
| dnaJ | dnaK | FP2_12310 | FP2_12320 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
| dnaJ | dnaK-2 | FP2_12310 | FP2_26120 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
STRING v12.5 is now available!
