nnrD protein (Faecalibacterium prausnitzii L26)

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nnrD

yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (299 aa)

Predicted Functional Partners:

FP2_20000

0.995

FP2_12470

0.958

FP2_15460

0.958

FP2_15640

0.813

groL

0.783

FP2_25800

0.762

FP2_15630

0.752

cobB

0.675

FP2_15900

0.606

FP2_26830

0.595

Your Current Organism:

Faecalibacterium prausnitzii L26

NCBI taxonomy Id: 718252
Other names: F. prausnitzii L2-6, Faecalibacterium prausnitzii L2-6, Faecalibacterium prausnitzii str. L2-6, Faecalibacterium prausnitzii strain L2-6, butyrate-producing bacterium L2-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FP2_12470	FP2_15640	FP2_12470	FP2_15640	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	Small GTP-binding protein domain.	0.749
FP2_12470	FP2_20000	FP2_12470	FP2_20000	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.	0.890
FP2_12470	nnrD	FP2_12470	FP2_15650	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.958
FP2_15460	FP2_15640	FP2_15460	FP2_15640	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	Small GTP-binding protein domain.	0.749
FP2_15460	FP2_20000	FP2_15460	FP2_20000	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.	0.890
FP2_15460	nnrD	FP2_15460	FP2_15650	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.958
FP2_15630	FP2_15640	FP2_15630	FP2_15640	Hypothetical protein.	Small GTP-binding protein domain.	0.761
FP2_15630	cobB	FP2_15630	FP2_15660	Hypothetical protein.	NAD-dependent protein deacetylases, SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.	0.545
FP2_15630	nnrD	FP2_15630	FP2_15650	Hypothetical protein.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.752
FP2_15640	FP2_12470	FP2_15640	FP2_12470	Small GTP-binding protein domain.	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	0.749
FP2_15640	FP2_15460	FP2_15640	FP2_15460	Small GTP-binding protein domain.	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	0.749
FP2_15640	FP2_15630	FP2_15640	FP2_15630	Small GTP-binding protein domain.	Hypothetical protein.	0.761
FP2_15640	cobB	FP2_15640	FP2_15660	Small GTP-binding protein domain.	NAD-dependent protein deacetylases, SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.	0.597
FP2_15640	groL	FP2_15640	FP2_04990	Small GTP-binding protein domain.	Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.463
FP2_15640	nnrD	FP2_15640	FP2_15650	Small GTP-binding protein domain.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.813
FP2_15900	nnrD	FP2_15900	FP2_15650	Glycogen/starch/alpha-glucan phosphorylases; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.606
FP2_20000	FP2_12470	FP2_20000	FP2_12470	NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	0.890
FP2_20000	FP2_15460	FP2_20000	FP2_15460	NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.	Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.	0.890
FP2_20000	nnrD	FP2_20000	FP2_15650	NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.995
FP2_25800	nnrD	FP2_25800	FP2_15650	Conserved hypothetical nucleotide-binding protein.	yjeF C-terminal region, hydroxyethylthiazole kinase-related; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.762

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