Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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textmining
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
Score
FP2_30180Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (663 aa)    
Predicted Functional Partners:
FP2_30190
Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit.
 
 
 0.994
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.973
FP2_22550
ATP-dependent DNA helicase, RecQ family.
  
 
 0.711
truB
tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
 0.670
FP2_23420
Superfamily II DNA/RNA helicases, SNF2 family.
  
 
 0.645
recF
recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
  
  
 0.585
FP2_19860
Cation/multidrug efflux pump.
   
 
 0.563
FP2_19280
Glutamate synthase domain 2.
     
 0.558
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.510
FP2_15500
Hypothetical protein.
  
     0.482
Your Current Organism:
Faecalibacterium prausnitzii L26
NCBI taxonomy Id: 718252
Other names: F. prausnitzii L2-6, Faecalibacterium prausnitzii L2-6, Faecalibacterium prausnitzii str. L2-6, Faecalibacterium prausnitzii strain L2-6, butyrate-producing bacterium L2-6
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