STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M91_06400Small ubiquitin-related modifier 1. (80 aa)    
Predicted Functional Partners:
SAE1
SUMO-activating enzyme subunit 1.
   
 0.907
SENP1
Sentrin-specific protease 1.
   
 0.887
PIAS1
E3 SUMO-protein ligase PIAS1.
    
 0.880
RANBP2
E3 SUMO-protein ligase RanBP2.
   
 0.874
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.873
RANGAP1
Ran GTPase-activating protein 1.
    
 0.857
PIAS2
E3 SUMO-protein ligase PIAS2.
    
 0.850
ENSBMUP00000029324
annotation not available
   
 0.835
UBE2I
SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.835
SENP2
Sentrin-specific protease 2.
   
 0.828
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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