STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIF21BKinesin-like protein KIF21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1520 aa)    
Predicted Functional Partners:
STK36
Serine/threonine-protein kinase 36.
   
 0.871
SMO
Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 0.780
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.697
MKLN1
Muskelin 1.
   
  
 0.646
GLIS3
Zinc finger protein GLIS3.
    
 0.645
GLI2
GLI family zinc finger 2.
    
 0.645
LOC102268721
Transcriptional activator GLI3-like.
    
 0.645
GLIS1
Zinc finger protein GLIS1.
    
 0.645
GLI1
Zinc finger protein GLI1.
    
 0.645
TRIM3
Tripartite motif-containing protein 3.
    
 
 0.625
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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