node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BARD1 | BRCA1 | ENSBMUP00000030296 | ENSBMUP00000026640 | BRCA1-associated RING domain protein 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
BARD1 | BRCA2 | ENSBMUP00000030296 | ENSBMUP00000018023 | BRCA1-associated RING domain protein 1. | Breast cancer 2 susceptibility protein. | 0.953 |
BARD1 | BRIP1 | ENSBMUP00000030296 | ENSBMUP00000006881 | BRCA1-associated RING domain protein 1. | BRCA1 interacting protein C-terminal helicase 1. | 0.898 |
BARD1 | FANCD2 | ENSBMUP00000030296 | ENSBMUP00000014506 | BRCA1-associated RING domain protein 1. | Fanconi anemia complementation group D2. | 0.669 |
BARD1 | PALB2 | ENSBMUP00000030296 | ENSBMUP00000030316 | BRCA1-associated RING domain protein 1. | PALB2_WD40 domain-containing protein. | 0.942 |
BARD1 | RAD51 | ENSBMUP00000030296 | ENSBMUP00000001341 | BRCA1-associated RING domain protein 1. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.879 |
BARD1 | RAD51B | ENSBMUP00000030296 | ENSBMUP00000016813 | BRCA1-associated RING domain protein 1. | DNA repair protein RAD51-like protein 2. | 0.818 |
BARD1 | RAD51C | ENSBMUP00000030296 | ENSBMUP00000028173 | BRCA1-associated RING domain protein 1. | DNA repair protein RAD51-like protein 3. | 0.842 |
BARD1 | RAD51D | ENSBMUP00000030296 | ENSBMUP00000017457 | BRCA1-associated RING domain protein 1. | RAD51 paralog D. | 0.841 |
BRCA1 | BARD1 | ENSBMUP00000026640 | ENSBMUP00000030296 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1-associated RING domain protein 1. | 0.999 |
BRCA1 | BRCA2 | ENSBMUP00000026640 | ENSBMUP00000018023 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Breast cancer 2 susceptibility protein. | 0.999 |
BRCA1 | BRIP1 | ENSBMUP00000026640 | ENSBMUP00000006881 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 interacting protein C-terminal helicase 1. | 0.991 |
BRCA1 | FANCD2 | ENSBMUP00000026640 | ENSBMUP00000014506 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Fanconi anemia complementation group D2. | 0.926 |
BRCA1 | M91_04762 | ENSBMUP00000026640 | ENSBMUP00000018762 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 26S proteasome complex subunit DSS1. | 0.907 |
BRCA1 | PALB2 | ENSBMUP00000026640 | ENSBMUP00000030316 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | PALB2_WD40 domain-containing protein. | 0.999 |
BRCA1 | RAD51 | ENSBMUP00000026640 | ENSBMUP00000001341 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.990 |
BRCA1 | RAD51B | ENSBMUP00000026640 | ENSBMUP00000016813 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA repair protein RAD51-like protein 2. | 0.788 |
BRCA1 | RAD51C | ENSBMUP00000026640 | ENSBMUP00000028173 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA repair protein RAD51-like protein 3. | 0.846 |
BRCA1 | RAD51D | ENSBMUP00000026640 | ENSBMUP00000017457 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | RAD51 paralog D. | 0.813 |
BRCA2 | BARD1 | ENSBMUP00000018023 | ENSBMUP00000030296 | Breast cancer 2 susceptibility protein. | BRCA1-associated RING domain protein 1. | 0.953 |