STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TYK2Non-specific protein-tyrosine kinase. (1187 aa)    
Predicted Functional Partners:
IFNAR1
Interferon alpha/beta receptor 1.
   
 0.999
STAT2
Signal transducer and activator of transcription.
   
 0.998
IL12RB1
Interleukin-12 receptor subunit beta-1.
   
 0.996
IL10RB
Interleukin-10 receptor subunit beta.
   
 0.995
SOCS3
Suppressor of cytokine signaling 3.
   
 0.994
JAK2
Tyrosine-protein kinase.
  
0.993
STAT1
Signal transducer and activator of transcription.
   
 0.989
JAK1
Janus kinase 1.
  
 
0.988
IL10RA
Interleukin-10 receptor subunit alpha.
   
 0.987
STAT3
Signal transducer and activator of transcription.
   
 0.987
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.