Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEV68778.1sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. (298 aa)    
Predicted Functional Partners:
AEV67113.1
PFAM: Stage II sporulation protein E (SpoIIE); TIGRFAM: stage II sporulation protein E.
  
  
 0.927
AEV69941.1
PFAM: Stage II sporulation protein E (SpoIIE); TIGRFAM: stage II sporulation protein E.
  
  
 0.927
AEV68777.1
RNA polymerase, sigma 29 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.906
AEV68776.1
RNA polymerase, sigma subunit, RpsG/SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.904
AEV67342.1
PFAM: Stage II sporulation protein R (spore_II_R); TIGRFAM: stage II sporulation protein R.
 
   
 0.878
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.866
AEV68081.1
PFAM: Putative stage IV sporulation protein YqfD; TIGRFAM: sporulation protein YqfD; manually curated.
  
   
 0.843
AEV68672.1
TIGRFAM: stage III sporulation protein AA.
  
  
 0.832
AEV67073.1
PFAM: YabP family; TIGRFAM: sporulation protein YabP.
  
  
 0.811
AEV68115.1
PFAM: Integral membrane protein DUF95; TIGRFAM: stage II sporulation protein M.
  
  
 0.803
Your Current Organism:
Hungateiclostridium clariflavum
NCBI taxonomy Id: 720554
Other names: Clostridium clariflavum DSM 19732, Clostridium clariflavum EBR45, H. clariflavum DSM 19732, Hungateiclostridium clariflavum DSM 19732
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