Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
larCTIGR00299 family protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (402 aa)    
Predicted Functional Partners:
AEV69613.1
NCAIR mutase-like protein; PFAM: AIR carboxylase.
 
  
 0.984
AEV69288.1
TIGR00268 family protein; PFAM: Asparagine synthase; TIGRFAM: TIGR00268 family protein.
  
 0.945
AEV69611.1
PFAM: Radical SAM superfamily; TIGRFAM: radical SAM protein, TIGR01212 family; manually curated.
       0.712
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
       0.660
AEV69614.1
Hypothetical protein; PFAM: Domain of unknown function (DUF2520); Rossmann-like domain.
       0.570
AEV67099.1
PFAM: Cobalt transport protein; TIGRFAM: cobalt ABC transporter, permease protein CbiQ.
 
    0.559
AEV67098.1
ABC-type Co2+ transport system, permease component; PFAM: Cobalt uptake substrate-specific transmembrane region; TIGRFAM: cobalamin biosynthesis protein CbiM.
 
    0.551
cbiM
Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.458
cinA
PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain.
       0.431
AEV67112.1
Hypothetical protein; PFAM: Domain of unknown function (DUF362).
 
     0.411
Your Current Organism:
Hungateiclostridium clariflavum
NCBI taxonomy Id: 720554
Other names: Clostridium clariflavum DSM 19732, Clostridium clariflavum EBR45, H. clariflavum DSM 19732, Hungateiclostridium clariflavum DSM 19732
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