STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DanaGF27365Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (85 aa)    
Predicted Functional Partners:
DanaGF17728
Uncharacterized protein.
   
 0.857
DanaGF18646
Histone acetyltransferase type B catalytic subunit.
    
 0.781
DanaGF11355
Uncharacterized protein, isoform A.
    
 0.765
DanaGF16580
Uncharacterized protein.
    
 0.759
DanaGF24008
Uncharacterized protein.
    
 0.729
DanaGF13670
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
 0.709
DanaGF13400
Uncharacterized protein, isoform A.
    
 0.663
DanaGF21991
SET domain-containing protein.
    
 0.663
DanaGF16859
Ku domain-containing protein.
    
 0.661
DanaGF15783
Ubiquitin-like domain-containing protein.
   
 0.661
Your Current Organism:
Drosophila ananassae
NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.