DgriGH18183 protein (Drosophila grimshawi) - STRING interaction network

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Score

DgriGH18183

Ubiquitin carboxyl-terminal hydrolase. (901 aa)

Predicted Functional Partners:

DgriGH14771

0.955

DgriGH13876

0.955

DgriGH15714

0.949

DgriGH13542

0.940

DgriGH16528

0.926

DgriGH10063

0.911

DgriGH13592

0.909

DgriGH11165

0.788

DgriGH13358

0.785

DgriGH19872

0.716

Your Current Organism:

Drosophila grimshawi

NCBI taxonomy Id: 7222
Other names: D. grimshawi, Idiomyia grimshawi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DgriGH10063	DgriGH11165	B4JD38	B4JDD4	GH10063.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.761
DgriGH10063	DgriGH13358	B4JD38	B4JPP9	GH10063.	GH13358.	0.939
DgriGH10063	DgriGH13542	B4JD38	B4JPL3	GH10063.	GH13542.	0.999
DgriGH10063	DgriGH13592	B4JD38	B4JPV4	GH10063.	GH13592.	0.917
DgriGH10063	DgriGH13876	B4JD38	B4JP61	GH10063.	GH13876.	0.761
DgriGH10063	DgriGH14771	B4JD38	B4J3P9	GH10063.	GH14771.	0.761
DgriGH10063	DgriGH15714	B4JD38	B4IZ29	GH10063.	GH15714.	0.995
DgriGH10063	DgriGH16528	B4JD38	B4J141	GH10063.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.996
DgriGH10063	DgriGH18183	B4JD38	B4JG44	GH10063.	Ubiquitin carboxyl-terminal hydrolase.	0.911
DgriGH11165	DgriGH10063	B4JDD4	B4JD38	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GH10063.	0.761
DgriGH11165	DgriGH13542	B4JDD4	B4JPL3	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GH13542.	0.883
DgriGH11165	DgriGH13592	B4JDD4	B4JPV4	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GH13592.	0.999
DgriGH11165	DgriGH15714	B4JDD4	B4IZ29	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GH15714.	0.934
DgriGH11165	DgriGH18183	B4JDD4	B4JG44	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Ubiquitin carboxyl-terminal hydrolase.	0.788
DgriGH11165	DgriGH19872	B4JDD4	B4J993	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GH19872.	0.433
DgriGH13358	DgriGH10063	B4JPP9	B4JD38	GH13358.	GH10063.	0.939
DgriGH13358	DgriGH13542	B4JPP9	B4JPL3	GH13358.	GH13542.	0.902
DgriGH13358	DgriGH13876	B4JPP9	B4JP61	GH13358.	GH13876.	0.428
DgriGH13358	DgriGH14771	B4JPP9	B4J3P9	GH13358.	GH14771.	0.428
DgriGH13358	DgriGH15714	B4JPP9	B4IZ29	GH13358.	GH15714.	0.870