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CG17003 protein (fruit fly) - STRING interaction network
"CG17003" - Alpha-tubulin N-acetyltransferase 2 in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG17003Alpha-tubulin N-acetyltransferase 2; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (287 aa)    
Predicted Functional Partners:
l(1)1Bi
Lethal (1) 1Bi; DNA binding; DNA-directed DNA polymerase activity. It is involved in the biological process described with- transcription, DNA-templated (1133 aa)
           
  0.699
CG15027
annotation not available (180 aa)
           
  0.694
CG7296
annotation not available (161 aa)
     
   
  0.659
Ssb-c31a
RNA polymerase II transcriptional coactivator; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). Binds specifically to the NssBF element, a short nucleotide sequence of the 1731 retrotransposon, to repress promoter activity (110 aa)
           
  0.652
CG12007
LD31216p; Rab geranylgeranyltransferase activity. It is involved in the biological process described with- regulation of cell shape; protein geranylgeranylation; neurogenesis; cell adhesion (515 aa)
           
  0.597
hui
Hase und igel, isoform A; It is involved in the biological process described with- wing disc development (202 aa)
           
  0.592
CG5623
annotation not available (279 aa)
     
        0.575
CG15611
Uncharacterized protein, isoform A; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with- response to endoplasmic reticulum stress; positive regulation of Rho protein signal transduction (508 aa)
           
  0.548
Aats-trp
Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family (430 aa)
           
  0.482
Aats-val
Valyl-tRNA synthetase, isoform C; aminoacyl-tRNA editing activity; ATP binding; glutamate-tRNA ligase activity; valine-tRNA ligase activity. It is involved in the biological process described with- valyl-tRNA aminoacylation; neurogenesis; Belongs to the class-I aminoacyl-tRNA synthetase family (1055 aa)
           
  0.481
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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