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l(1)sc protein (fruit fly) - STRING interaction network
"l(1)sc" - Achaete-scute complex protein T3 in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
l(1)scAchaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system (257 aa)    
Predicted Functional Partners:
emc
Protein extra-macrochaetae; Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer (199 aa)
       
 
  0.968
ac
Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development (201 aa)
     
 
0.963
sc
Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation (345 aa)
     
 
0.962
da
Daughterless is a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation (710 aa)
     
 
  0.925
ind
Intermediate neuroblasts defective; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor binding (320 aa)
     
 
  0.784
SoxN
SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance (572 aa)
     
 
  0.777
E(spl)
Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ (179 aa)
       
 
  0.728
jumu
Jumeau is a multi-functional transcription factor and acts upstream of a Polo-kinase dependent pathway in one report. Its roles include asymmetric protein localization, chromatin modification, dendrite formation and organ (eye, wing and bristle) development (719 aa)
     
 
  0.704
ato
Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection (312 aa)
     
   
  0.695
vnd
Homeobox protein vnd; Ventral nervous system defective (Vnd) is a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. Vnd roles include patterning of the neuroectoderm, formation and specification of ventral neuroblasts and proper development of their cell lineages (723 aa)
     
 
  0.684
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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