| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| E(spl) | ac | FBpp0084335 | FBpp0070071 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | 0.993 |
| E(spl) | ato | FBpp0084335 | FBpp0081318 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection | 0.917 |
| E(spl) | da | FBpp0084335 | FBpp0304504 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Daughterless is a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation | 0.821 |
| E(spl) | emc | FBpp0084335 | FBpp0072477 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Protein extra-macrochaetae; Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer | 0.603 |
| E(spl) | l(1)sc | FBpp0084335 | FBpp0070073 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Achaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.728 |
| E(spl) | sc | FBpp0084335 | FBpp0070072 | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation | 0.993 |
| SoxN | ac | FBpp0079335 | FBpp0070071 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | 0.707 |
| SoxN | ato | FBpp0079335 | FBpp0081318 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection | 0.612 |
| SoxN | da | FBpp0079335 | FBpp0304504 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Daughterless is a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation | 0.491 |
| SoxN | ind | FBpp0079335 | FBpp0306007 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Intermediate neuroblasts defective; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor binding | 0.509 |
| SoxN | l(1)sc | FBpp0079335 | FBpp0070073 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Achaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.777 |
| SoxN | sc | FBpp0079335 | FBpp0070072 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation | 0.555 |
| SoxN | vnd | FBpp0079335 | FBpp0070105 | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | Homeobox protein vnd; Ventral nervous system defective (Vnd) is a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. Vnd roles include patterning of the neuroectoderm, formation and specification of ventral neuroblasts and proper development of their cell lineages | 0.776 |
| ac | E(spl) | FBpp0070071 | FBpp0084335 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Enhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs- 5’-CACNAG-3’ | 0.993 |
| ac | SoxN | FBpp0070071 | FBpp0079335 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | SoxNeuro, isoform B; Sequence-specific DNA binding transcription factor activity; protein binding; chromatin DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with- nervous system development; regulation of Wnt signaling pathway; positive regulation of transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-templated; axon guidance | 0.707 |
| ac | ato | FBpp0070071 | FBpp0081318 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection | 0.884 |
| ac | da | FBpp0070071 | FBpp0304504 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Daughterless is a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation | 0.985 |
| ac | emc | FBpp0070071 | FBpp0072477 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Protein extra-macrochaetae; Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer | 0.993 |
| ac | ind | FBpp0070071 | FBpp0306007 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Intermediate neuroblasts defective; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor binding | 0.688 |
| ac | l(1)sc | FBpp0070071 | FBpp0070073 | Achaete-scute complex protein T5; Achaete is a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development | Achaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.963 |
