Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG18273LD21943p. (1377 aa)    
Predicted Functional Partners:
CG14230
Probable RNA-binding protein CG14230; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome.
   
 
 0.916
CG12499
Uncharacterized protein; It is involved in the biological process described with: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
   
  
 0.897
flr
Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Essential for organismal and cell viability. Required for the development of normal wing cell planar polarity.
   
 
 0.850
capt
Adenylyl cyclase-associated protein; Capulet (capt) encodes a conserved actin binding protein that functions across eukaryotes to negatively regulate actin filament assembly. Different types of actin filament formation are differentially affected by the loss of capt.
   
 
 0.830
CG15098
LP21121p.
      
 0.825
cpb
Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.
   
 
 0.821
coro
Coronin; Actin filament binding. It is involved in the biological process described with: defense response to fungus; actin filament organization; adult somatic muscle development; Belongs to the WD repeat coronin family.
   
 
 0.771
CG4554
DRIM domain-containing protein.
   
  
 0.707
CG3071
LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I.
   
  
 0.696
l(1)G0004
RNA-binding protein pno1; RNA binding.
   
  
 0.671
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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