Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG13377RE15974p. (330 aa)    
Predicted Functional Partners:
SCOT
Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Belongs to the 3-oxoacid CoA-transferase family.
   
 
 0.959
Hmgcl
3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A; hydroxymethylglutaryl-CoA lyase activity. It is involved in the biological process described with: leucine metabolic process; leucine catabolic process; lipid metabolic process; ketone body biosynthetic process.
   
 
 0.915
CG3638
Protein tweety-2; Probable chloride channel; Belongs to the tweety family.
    
 
 0.865
CG32572
FI24431p1.
   
  
 0.819
ACC
Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity.
      
 0.644
pxb
Pxb (pxb) encodes a protein involved in response to ethanol, long-term memory and regulation of hemocyte proliferation.
      
 0.597
qsm
Quasimodo, isoform A; Quasimodo (qsm) encodes a light-responsive factor of the circadian clock. It controls the rhythmic firing of clock neurons via the K[+] channel and the Na[+] K[+] Cl[-] cotransporter encoded by Shaw and NKCC respectively.
   
    0.583
CG3368
DUF2428 domain-containing protein; It is involved in the biological process described with: tRNA methylation.
   
  
 0.581
Cad96Ca
Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth.
   
    0.533
Hmgs
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.480
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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