Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG13367EG:115C2.8 protein; It is involved in the biological process described with: chromatin organization. (408 aa)    
Predicted Functional Partners:
CG3815
GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated.
   
 
 0.996
CG15356
FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated.
    
 
 0.935
MRG15
NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.
   
 
 0.933
lid
Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
   
 
 0.906
Sin3A
Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation.
    
 
 0.833
Caf1-55
Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...]
    
   0.829
Bub1
Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.
    
   0.809
RpL34a
Ribosomal protein L34a, isoform A; Structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; ribosome biogenesis; cytoplasmic translation.
   
   0.799
HDAC1
Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...]
   
 
 0.793
CG12935
LD08826p; It is involved in the biological process described with: nervous system development.
      
 0.603
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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