STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdkProtein sidekick; Participates in homotypic or heterotypic interactions in the eye during pattern formation to prevent extra cells from joining the precluster and differentiating as photoreceptor cells. (2265 aa)    
Predicted Functional Partners:
Magi
Magi, isoform A; Magi (Magi) encodes a molecular scaffolding protein that is involved in adherens junction (AJ) organization. Magi is ubiquitously expressed and its product localizes at AJ with the Par polarity complex.
   
 
 0.632
BicC
Protein bicaudal C; RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression.
   
 
 0.617
cno
Canoe, isoform E; Canoe (cno) encodes a scaffold protein in adherens junctions that is involved in morphogenesis in a variety of tissues.
   
 
 0.614
CG5815
Protein SPT2 homolog; Histone binding; DNA binding. It is involved in the biological process described with: nucleosome assembly; histone exchange; regulation of chromatin assembly; regulation of transcription, DNA-templated.
   
 
 0.556
CG9799
LD47749p; It is involved in the biological process described with: rRNA processing.
 
      0.501
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
    
 
 0.497
bark
Protein bark beetle; Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation. Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis. Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions. Required for the accumulation of Gli at tricellular junctions.
   
  
 0.495
otk
Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
   
 
0.481
Cad87A
Cadherin-87A; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
   
 
 0.477
bves
Bves, isoform A; cAMP binding.
   
  
 0.450
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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