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Hmt4-20 protein (fruit fly) - STRING interaction network
"Hmt4-20" - Histone-lysine N-methyltransferase Suv4-20 in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Hmt4-20Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically trimethylates ’Lys-20’ of histone H4. H4 ’Lys-20’ trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily (1300 aa)    
Predicted Functional Partners:
FBpp0091126
His4-CG33881; DNA binding; protein heterodimerization activity. It is involved in the biological process described with- chromatin assembly or disassembly; nucleosome assembly (103 aa)
       
  0.962
pr-set7
Histone-lysine N-methyltransferase pr-set7; Histone methyltransferase that specifically monomethylates ’Lys-20’ of histone H4. H4 ’Lys-20’ monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis; Belongs to the class V-like SAM-binding methyltransferase superfa [...] (691 aa)
     
   
  0.955
Set1
Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates ’Lys-4’ of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription (1641 aa)
     
   
  0.947
Su(var)3-9
Histone-lysine N-methyltransferase Su(var)3-9; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3 using monomethylated H3 ’Lys- 9’ as substrate. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation; Belongs to the c [...] (635 aa)
     
   
  0.914
FBpp0091124
His4-CG33879; DNA binding; protein heterodimerization activity. It is involved in the biological process described with- chromatin assembly or disassembly; nucleosome assembly (103 aa)
       
  0.911
FBpp0091122
His4-CG33877; DNA binding; protein heterodimerization activity. It is involved in the biological process described with- chromatin assembly or disassembly; nucleosome assembly (103 aa)
       
  0.911
FBpp0091114
His4-CG33869; DNA binding; protein heterodimerization activity. It is involved in the biological process described with- chromatin assembly or disassembly; nucleosome assembly (103 aa)
       
  0.911
gpp
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity (2137 aa)
     
   
  0.853
Set2
Probable histone-lysine N-methyltransferase CG1716; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity) (2362 aa)
     
   
  0.847
Bzd
SET and MYND domain containing, class 3; Zinc ion binding; translation initiation factor activity. It is involved in the biological process described with- translational initiation (468 aa)
     
   
  0.847
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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