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Hmt4-20 protein (fruit fly) - STRING interaction network
"Hmt4-20" - Histone methyltransferase 4-20 in Drosophila melanogaster
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Hmt4-20Histone methyltransferase 4-20; Histone methyltransferase that specifically trimethylates ’Lys-20’ of histone H4. H4 ’Lys-20’ trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation (1300 aa)    
Predicted Functional Partners:
CG10947
FI04554p (404 aa)
     
 
    0.900
Plod
Procollagen lysyl hydroxylase (721 aa)
         
    0.900
pr-set7
Pr-set7; Histone methyltransferase that specifically monomethylates ’Lys-20’ of histone H4. H4 ’Lys-20’ monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (691 aa)
     
   
  0.870
G9a
G9a (1657 aa)
     
   
  0.739
Su(var)3-9
Suppressor of variegation 3-9; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3 using monomethylated H3 ’Lys- 9’ as substrate. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation (635 aa)
     
   
  0.691
Set1
Histone methyltransferase activity (H3-K4 specific); Catalytic component of the SET1 complex that specifically di- and trimethylates ’Lys-4’ of histone H3 and is the main di- and trimethyltransferase thoughout development. Set1- dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription (1641 aa)
     
   
  0.550
CG3353
Zinc ion binding (393 aa)
     
   
  0.489
Amun
Amun (550 aa)
     
        0.477
Bzd
Buzidau (468 aa)
     
   
  0.460
Set2
Set2; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity) (2362 aa)
     
   
  0.438
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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