Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG32812EG:114D9.1 protein; Calcium ion binding. It is involved in the biological process described with: negative regulation of phosphatase activity. (225 aa)    
Predicted Functional Partners:
Pp2B-14D
Serine/threonine-protein phosphatase 2B catalytic subunit 2; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily.
    
 
 0.631
CanA-14F
Serine/threonine-protein phosphatase 2B catalytic subunit 3; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
    
 
 0.612
Nhe2
Na[+]/H[+] hydrogen exchanger 2 (Nhe2) encodes a Na-H exchanger of the SLC family 9A that increases intracellular pH. The product of Nhe2 activity promotes proliferation, morphogenesis and planar cell polarity, and contributes to oncogene-induced metastatic cell behaviors; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
    
 
 0.608
Ptp36E
Protein tyrosine phosphatase 36E (Ptp36E) encodes a tyrosine-specific protein phosphatase. It is probably a cytoplasmic protein, as it lacks a predicted transmembrane domain, but little is known about its function.
    
 
 0.599
CG17598
GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.
      
 0.591
CG31469
GEO10716p1; Protein arginine phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: peptidyl-N-phospho-arginine dephosphorylation.
      
 0.583
CanA1
Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily.
    
 
 0.575
CG17746
LD28127p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.572
CG7115
Uncharacterized protein, isoform A; Cation binding; magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.567
CG10417
Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.564
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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