• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
rush protein (fruit fly) - STRING interaction network
"rush" - Pleckstrin homology domain-containing family F member 1 homolog in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rushPleckstrin homology domain-containing family F member 1 homolog; Functions in the regulation of endosome morphology and late endosome formation. Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes. Important for localization of Gdi to the endosomal membranes. May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and [...] (316 aa)    
Predicted Functional Partners:
fab1
Putative 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing (1809 aa)
     
   
  0.822
RagC-D
Ras-related GTP binding C/D ortholog; GTPase activity; protein heterodimerization activity; GTP binding. It is involved in the biological process described with- cellular response to amino acid stimulus; positive regulation of TOR signaling (385 aa)
       
 
  0.817
Atg8a
Autophagy-related 8a (Atg8a) is a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a roles include autophagosome formation, maintaining neuromuscular function and normal lifespan (121 aa)
     
 
  0.788
Atg8b
Autophagy-related 8b, isoform A; Protein tag. It is involved in the biological process described with- macroautophagy; Belongs to the ATG8 family (120 aa)
     
 
  0.773
Atg6
Beclin-1-like protein; Autophagy-related 6 is a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis (422 aa)
       
 
  0.744
Ndfip
Nedd4 family interacting protein (Ndfip) interacts with the ubiquitin ligases Nedd4 and Su(dx) and regulates Notch signaling (267 aa)
     
 
  0.732
Rbsn-5
Rabenosyn-5 is a Rab5-binding effector that controls entry of endocytosed cargo into the early endosome (505 aa)
           
  0.719
RagA-B
Ras-related GTP binding A/B (RagA-B) is a Ras family GTPase that forms a heterodimer with RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to Tor activation by recruiting it to the lysosome (311 aa)
     
 
  0.689
RpL23A
Ribosomal protein L23A; Structural constituent of ribosome; nucleotide binding. It is involved in the biological process described with- translation; centrosome duplication; Belongs to the universal ribosomal protein uL23 family (277 aa)
           
  0.670
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP (443 aa)
       
 
  0.657
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (8%) [HD]