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O-fut2 protein (fruit fly) - STRING interaction network
"O-fut2" - O-fucosyltransferase 2 in Drosophila melanogaster
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
O-fut2O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of a number of protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families (490 aa)    
Predicted Functional Partners:
O-fut1
O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fu [...] (402 aa)
     
 
  0.930
CG31619
Metalloendopeptidase activity (1394 aa)
         
  0.901
CG30046
FI20258p1 (839 aa)
     
 
    0.900
CG17739
Serine-type endopeptidase inhibitor activity (873 aa)
     
 
    0.900
CG6953
Fat-spondin (763 aa)
     
 
    0.900
CG6232
Lonely heart (EC-3.4.24.-) (902 aa)
         
    0.900
CG4096
Metalloendopeptidase activity (1023 aa)
         
    0.900
CG30203
Serine-type endopeptidase inhibitor activity (924 aa)
         
    0.900
unc-5
Unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5 (1072 aa)
         
    0.900
CG14869
Metalloendopeptidase activity (1688 aa)
         
    0.900
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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