STRINGSTRING
Actn protein (fruit fly) - STRING interaction network
"Actn" - Alpha actinin in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
ActnAlpha actinin; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (917 aa)    
Predicted Functional Partners:
Tm2
Actin binding; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis (284 aa)
     
 
  0.990
Vinc
Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane (By similarity) (961 aa)
     
  0.982
Act79B
Actin 79B; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa)
     
  0.978
up
Upheld; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (397 aa)
     
 
  0.977
Ald
Aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases) (363 aa)
     
  0.976
Zasp52
Z band alternatively spliced PDZ-motif protein 52; Regulator of cell matrix adhesion having two related functions, one upstream of Actn organizing the Z line and the other downstream of integrins regulating assembly of integrin adhesion sites. Also required for the formation of myotendinous junctions in muscles (2194 aa)
     
  0.974
Prm
Paramyosin; Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles (879 aa)
     
 
  0.971
parvin
Actin binding (367 aa)
     
 
  0.966
Mhc
Myosin heavy chain; Muscle contraction (1962 aa)
     
 
  0.965
Mlc2
Myosin light chain 2 (222 aa)
     
 
  0.943
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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