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CG3857 protein (fruit fly) - STRING interaction network
"CG3857" - GTP binding in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG3857GTP binding; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity) (487 aa)    
Predicted Functional Partners:
nonC
Protein kinase activity; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1 (3218 aa)
     
  0.977
tsu
Tsunagi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed-14973490, PubMed-24967911). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed-20946982, PubMed-20946983). The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed-24967911). Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed-11691839) (165 aa)
       
  0.957
CG6729
Protein smg-8 homolog; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity) (944 aa)
     
  0.956
Smg5
Smg5 (1177 aa)
     
 
  0.949
eRF1
Eukaryotic release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (447 aa)
         
  0.949
Upf1
Upf1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity) (1180 aa)
     
  0.946
Smg6
Smg6 (948 aa)
     
 
  0.943
Elf
Ef1alpha-like factor (619 aa)
     
 
  0.938
Upf3
Upf3 (492 aa)
         
  0.934
Upf2
Upf2 (1241 aa)
         
  0.931
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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