STRINGSTRING
trr protein (fruit fly) - STRING interaction network
"trr" - Trithorax-related in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
trrTrithorax-related; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates ’Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone- dependent manner causing H3 ’Lys-4’ trimethylation at ecdysone- inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh. Also requi [...] (2431 aa)    
Predicted Functional Partners:
wds
Will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’ (By similarity) (361 aa)
     
  0.997
Rbbp5
Retinoblastoma binding protein 5; Component of the SET1 complex that specifically di- and trimethylates ’Lys-4’ of histone H3 and of the MLL3/4 complex which also methylates histone H3 ’Lys-4’ (489 aa)
     
  0.977
ash2
Zinc ion binding; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N- methyltransferase trr and for trimethylation of ’Lys-4’ of histone H3. Plays a role in maintenance of transcriptionally active chromatin through [...] (556 aa)
     
  0.974
Lpt
Lost PHDs of trr (1482 aa)
 
 
  0.973
Utx
Histone demethylase activity (1136 aa)
     
  0.969
ptip
Transcription factor binding (2294 aa)
     
  0.955
Dpy-30L1
Dpy-30-like 1; Component of the SET1 complex that specifically di- and trimethylates ’Lys-4’ of histone H3 and of the MLL3/4 complex which also methylates histone H3 ’Lys-4’. Inhibits MTF-1 transcription factor activity (134 aa)
       
  0.954
Ncoa6
Nuclear receptor coactivator 6 (2467 aa)
     
  0.950
Mnn1
Menin 1 (763 aa)
       
  0.946
Dpy-30L2
Dpy-30-like 2 (98 aa)
       
  0.935
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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