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csw protein (fruit fly) - STRING interaction network
"csw" - Corkscrew in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cswCorkscrew; Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic trach [...] (945 aa)    
Predicted Functional Partners:
dos
Daughter of sevenless; Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development (878 aa)
       
  0.999
Src64B
Src oncogene at 64B; May play a role in the development of neural tissue and smooth muscle (552 aa)
     
  0.997
Egfr
Protein binding; Binds to four ligands- Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf- MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Req [...] (1426 aa)
       
  0.996
Ras85D
Protein binding; May mediate a signal that determines the fate of photoreceptor cells in the developing compound eye. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
     
  0.990
drk
Downstream of receptor kinase; Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (211 aa)
     
0.979
sev
Sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell (2554 aa)
       
  0.976
tor
Torso; Probable receptor with tyrosine-protein kinase activity. Required for determination of anterior and posterior terminal structures in the Drosophila embryo. The ligand of torso seems to be TSL (923 aa)
     
  0.976
sty
Sprouty; Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL- branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells (589 aa)
       
  0.975
Sos
Protein binding; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development (1596 aa)
     
  0.974
Pi3K92E
Pi3K92E (1088 aa)
     
  0.974
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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