STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D2hgdhD-2-hydroxyglutaric acid dehydrogenase (D2hgdh) encodes an enzyme involved in oxidation-reduction metabolism. (533 aa)    
Predicted Functional Partners:
L2HGDH
L-2-hydroxyglutarate dehydrogenase, isoform A; (S)-2-hydroxy-acid oxidase activity; 2-hydroxyglutarate dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process.
  
  
 0.873
CG7834
Uncharacterized protein, isoform A; Electron transfer activity. It is involved in the biological process described with: oxidative phosphorylation.
  
 
 0.871
wal
Walrus, isoform A; Walrus (wal) encodes a protein involved in the development of Malpighian tubules, gut and trachea.
  
 
 0.796
Etf-QO
Electron transfer flavoprotein-ubiquinone oxidoreductase (Etf-QO) encodes a mitochondrial membrane bound protein that acts as a hub with the product of wal and fuels electrons from fatty acid oxidation by matrix dehydrogenases into the respiratory chain.
   
  
 0.715
CG18003
L-lactate dehydrogenase activity; FMN binding; (S)-2-hydroxy-acid oxidase activity. It is involved in the biological process described with: lactate oxidation.
 
 
 0.699
Ing5
Inhibitor of growth family member 5 (Ing5) encodes a histone acetyltransferase that forms part of the Enok complex, which interacts with the product of elg1 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading.
 
 
    0.657
CG6191
Uncharacterized protein, isoform C; It is involved in the biological process described with: regulation of cell cycle.
      
 0.604
colt
Congested-like trachea protein; Putative mitochondrial carrier of unknown solute specificity. Required for gas-filling of the tracheal system at hatching time of the embryo and for normal epithelial morphogenesis of the wings.
   
  
 0.593
Idh
Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes.
  
 
 0.569
ND-75
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By sim [...]
  
 
 0.565
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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