STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pgd6-phosphogluconate dehydrogenase, decarboxylating; Phosphogluconate dehydrogenase (Pgd) is a cytosolic enzyme that catalyzes the oxidation of 6-phosphogluconate to ribulose 5-phosphate, with the concomitant reduction of NADP(+) to NADPH. Pgd and Zw are the two NADP(+) reducing enzymes in the pentose phosphate pathway (481 aa)    
Predicted Functional Partners:
Tal
Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
  
 
 0.998
Zw
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family
 
 
 0.998
CG17333
Probable 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate
  
 
 0.992
Rpi
Ribose-5-phosphate isomerase activity. It is involved in the biological process described with: age-dependent response to reactive oxygen species; pentose-phosphate shunt, non-oxidative branch
  
 
 0.991
CG30499
annotation not available
  
 0.991
Pgi
Glucose-6-phosphate isomerase activity; phosphogluconate dehydrogenase (decarboxylating) activity. It is involved in the biological process described with: glycolytic process; gluconeogenesis
  
  
 0.986
CG8036
CG8036, isoform B; Transketolase activity. It is involved in the biological process described with: regulation of chromatin silencing; cytoplasmic microtubule organization
  
 
 0.965
Pgm
Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family
  
  
 0.954
Idh
Isocitrate dehydrogenase (Idh) is a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP(+) to NADPH. Idh functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes
   
  
 0.922
CG7470
Delta-1-pyrroline-5-carboxylate synthase; Glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity; glutamate-5-semialdehyde dehydrogenase activity. It is involved in the biological process described with: germarium-derived female germ-line cyst formation; oxidation-reduction process; proline biosynthetic process; epithelium development; In the C-terminal section; belongs to the gamma- glutamyl phosphate reductase family
   
  
 0.917
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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