STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp4ae1Cytochrome P450 4ae1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (496 aa)    
Predicted Functional Partners:
Cpr65Ec
Cuticular protein 65Ec; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.602
alpha-Est10
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
      
 0.600
CG30344
GH23453p; Transporter activity. It is involved in the biological process described with: response to toxic substance; renal tubular secretion; transmembrane transport.
   
   0.560
CG7239
RE17389p; It is involved in the biological process described with: positive regulation of transcription, DNA-templated.
    
   0.522
pps
Protein partner of snf (pps) encodes a protein that is part of the machinery required for sex-specific splicing of the Sxl and tra pre-mRNAs.
    
   0.522
GstE10
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process; Belongs to the GST superfamily.
      
 0.511
sxe2
Sex-specific enzyme 2, isoform A; Carboxylic ester hydrolase activity; lipase activity. It is involved in the biological process described with: lipid catabolic process.
    
 
 0.496
Drsl1
Drosomycin-like C1; It is involved in the biological process described with: defense response to fungus.
      
 0.491
spok
Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.
  
 
 0.464
GluRIB
Glutamate receptor IB, isoform B; Ionotropic glutamate receptor activity; signaling receptor activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity. It is involved in the biological process described with: cation transport.
      
 0.461
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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