STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tempTempura, isoform A; Tempura (temp) encodes a protein-prenyltransferase subunit that regulates Notch signaling. (398 aa)    
Predicted Functional Partners:
betaggt-II
Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. Belongs to the protein prenyltransferase subunit beta family.
    
 0.998
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
   
 0.994
CG12007
LD31216p; Rab geranylgeranyltransferase activity. It is involved in the biological process described with: protein geranylgeranylation.
     
0.926
Ykt6
YKT6 v-SNARE; Protein-cysteine S-palmitoyltransferase activity; SNAP receptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; Belongs to the synaptobrevin family.
   
 
 0.806
CG4615
LD03007p; It is involved in the biological process described with: cytolysis.
   
    0.638
CG31342
FI13065p.
   
    0.566
Rab1
FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis.
    
 
 0.561
ProRS-m
Prolyl-tRNA synthetase, mitochondrial, isoform A; proline-tRNA ligase activity; ATP binding; glycine-tRNA ligase activity. It is involved in the biological process described with: glycyl-tRNA aminoacylation; prolyl-tRNA aminoacylation.
   
  
 0.506
Setd3
Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-74'. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
   
    0.502
alpha4GT1
Alpha1,4-galactosyltransferase 1; Transferase activity, transferring hexosyl groups; acetylgalactosaminyltransferase activity; alpha-1,4-N-acetylgalactosaminyltransferase activity. It is involved in the biological process described with: negative regulation of apoptotic process; glycosphingolipid biosynthetic process; glycolipid biosynthetic process.
   
    0.497
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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