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Vinc protein (fruit fly) - STRING interaction network
Vinculin in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VincVinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane (By similarity) (961 aa)    
Predicted Functional Partners:
rhea
Rhea (2836 aa)
     
  0.999
Pax
Paxillin (581 aa)
       
  0.999
mys
Myospheroid; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms- beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many e [...] (846 aa)
     
  0.991
alpha-Cat
Alpha Catenin; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with the armadillo protein (917 aa)
     
0.984
Actn
Alpha actinin; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (917 aa)
     
  0.982
CAP
CAP (2571 aa)
     
  0.969
Tm2
Actin binding; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis (284 aa)
     
  0.967
Tm1
Tropomyosin 1; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction (711 aa)
     
  0.964
zip
Zipper; Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis (2056 aa)
     
  0.963
arm
Armadillo; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (843 aa)
     
  0.952
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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