STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nmd360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (521 aa)    
Predicted Functional Partners:
CG10576
Uncharacterized protein, isoform A; Nucleic acid binding.
   
 
 0.997
Ns3
Large subunit GTPase 1 homolog; GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control.
   
 
 0.995
Non1
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
  
 
 0.994
eIF6
Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
   
 
 0.991
RpL24-like
Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).
   
 
 0.991
CG6769
LD10434p; Nucleic acid binding; zinc ion binding. It is involved in the biological process described with: ribosomal large subunit biogenesis.
   
 
 0.983
RpLP0-like
Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
   
 
 0.981
Ns1
Guanine nucleotide-binding protein-like 3 homolog; Nucleostemin 1 (Ns1) encodes a GTPase that is enriched in the peripheral granular components of nucleoli of most larval and adult cells. It is required for nucleolar release of the large ribosomal subunit. Depletion of the Ns1 product reduces viability of midgut imaginal island cells and ribosome abundance in polyploid cells; Belongs to the TRAFAC class YlqF/YawG GTPase family.
   
 
 0.979
CG3224
Zinc finger protein 593 homolog; Nucleic acid binding; zinc ion binding; ribosomal large subunit binding. It is involved in the biological process described with: ribosomal large subunit export from nucleus; Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
   
 
 0.976
RpL10
60S ribosomal protein L10; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal large subunit assembly; cytoplasmic translation.
    
 
 0.976
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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