STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bcn92Protein bcn92; It is involved in the biological process described with: iron-sulfur cluster assembly; Belongs to the complex I LYR family. (92 aa)    
Predicted Functional Partners:
Nfs1
Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 0.999
IscU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
   
 0.999
fh
Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family.
   
 0.998
mt:Cyt-b
Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
   
 
 0.992
ND-ACP
Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity); Belongs to the acyl carrier protein (ACP) family.
   
 
 0.972
Fdx2
Adrenodoxin-like protein 2, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
   
 0.965
Qtzl
Quetzalcoatl, isoform A; Cysteine desulfurase activity; pyridoxal phosphate binding. It is involved in the biological process described with: [2Fe-2S] cluster assembly; iron-sulfur cluster assembly.
   
 
 0.965
Fdx1
Adrenodoxin-like protein 1, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
   
 0.952
CG8043
GH14121p; RNA binding. It is involved in the biological process described with: iron-sulfur cluster assembly.
      
 0.939
MagR
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness.
   
  
 0.873
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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