STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zRegulatory protein zeste; Zeste (z) encodes a sequence-specific DNA-binding protein. It is often found in the proximal promoter region of many genes where it helps to recruit the BRM nucleosome remodeling complex. It is best known for the pairing-dependent repressive effects produced by some of its mutants on target genes, especially the w gene. (605 aa)    
Predicted Functional Partners:
TrxT
Thioredoxin-T; Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.
    
   0.994
Adk3
GM02629p; Adenosine kinase activity.
    
   0.994
CG14074
IP10578p.
    
   0.994
lwr
Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo.
    
   0.994
CG6227
LD41277p; ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome.
   
   0.935
Mfap1
Microfibrillar-associated protein 1; Required for pre-mRNA splicing.
   
 
 0.922
Sf3b1
Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 
 0.896
Prp38
Pre-mRNA-splicing factor 38; Required for pre-mRNA splicing; Belongs to the PRP38 family.
   
 
 0.895
Spx
Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 
 0.890
Sf3a1
Splicing factor 3a subunit 1; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; mitotic cell cycle; spermatogenesis.
   
   0.884
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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