STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eghBeta-1,4-mannosyltransferase egh; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system; Belongs to the glycosyltransferase 2 family. (457 aa)    
Predicted Functional Partners:
brn
Beta-1,3-galactosyltransferase brn; Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal- ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation.
      
 0.896
CG4572
Serine-type carboxypeptidase activity. It is involved in the biological process described with: dsRNA transport; proteolysis involved in cellular protein catabolic process; Belongs to the peptidase S10 family.
   
 
 0.852
beta4GalNAcTB
beta1,4-N-acetylgalactosaminyltransferase B (beta4GalNAcTB) encodes a Golgi glycosyltransferase that transfers N-acetylgalactosamine to N-acetylglucosamine residues of glycosphingolipids.
      
 0.832
beta4GalNAcTA
beta1,4-N-acetylgalactosaminyltransferase A (beta4GalNAcTA) encodes a acetylgalactosaminyltransferase involved in glycolipid biosynthesis. It contributes to the development of the neuromuscular junction.
   
  
 0.719
ninaC
Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina.
      
 0.663
Ars2
Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family.
   
  
 0.609
Gmer
Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
  
  
 0.549
GlcT
Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development.
  
  
 0.523
pcx
Protein pecanex; Involved in neurogenesis.
   
  
 0.518
aqz
Aaquetzalli, isoform A.
   
  
 0.516
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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