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STRINGSTRING
Seipin protein (fruit fly) - STRING interaction network
Seipin in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
SeipinSeipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis (370 aa)    
Predicted Functional Partners:
Lpin
Lipin, isoform A; Lipin (Lpin) plays a central role in fat body function and energy metabolism. Lpin works as a phosphatidate phosphatase required for normal insulin pathway signaling (1089 aa)
       
 
  0.907
CG3812
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with- phospholipid biosynthetic process; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family (343 aa)
     
   
  0.837
lds
Transcription termination factor 2; Lodestar (Lds) belongs to the helicase-related family and is part of the spindle assembly checkpoint engaged in the maintenance of chromosome/genome stability. It is required to load cohesin complexes onto the chromosomes during the embryonic cleavage mitoses. Absence of Lds leads to frequent chromosome loss and death of cells and embryos (1061 aa)
           
  0.826
Cct1
CTP-phosphocholine cytidylyltransferase 1, isoform A; Choline-phosphate cytidylyltransferase activity. It is involved in the biological process described with- oogenesis; determination of adult lifespan; imaginal disc-derived wing morphogenesis; phosphatidylcholine biosynthetic process; biosynthetic process; establishment of ommatidial planar polarity; endocytosis; eye development (526 aa)
           
  0.823
CG10671
FIT family protein CG10671; It is involved in the biological process described with- lipid storage (480 aa)
           
  0.799
fu12
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with- phospholipid biosynthetic process; behavioral response to ethanol (271 aa)
     
   
  0.797
mdy
O-acyltransferase; Midway (615 aa)
     
 
  0.769
Dhap-at
Dihydroxyacetone phosphate acyltransferase, isoform A; Glycerol-3-phosphate O-acyltransferase activity; glycerone-phosphate O-acyltransferase activity. It is involved in the biological process described with- ether lipid biosynthetic process; Belongs to the GPAT/DAPAT family (724 aa)
           
  0.744
mino
Minotaur, isoform A; Glycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with- phospholipid biosynthetic process; plasma membrane organization; piRNA metabolic process; Belongs to the GPAT/DAPAT family (850 aa)
       
 
  0.738
CG9471
CG9471, isoform A; NADPH dehydrogenase activity; biliverdin reductase activity. It is involved in the biological process described with- multicellular organism reproduction (204 aa)
           
  0.725
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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