STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SeipinSeipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa)    
Predicted Functional Partners:
spartin
Protein spartin; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.
   
  
 0.921
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: behavioral response to ethanol; phosphatidic acid biosynthetic process.
   
  
 0.894
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: phosphatidic acid biosynthetic process; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
      
 0.890
Dgat2
Diacylglycerol O-acyltransferase activity; O-acyltransferase activity. It is involved in the biological process described with: lipid droplet organization; mesoderm development; lipid metabolic process; triglyceride biosynthetic process.
      
 0.881
mdy
O-acyltransferase; Midway (mdy) encodes an acyl coenzyme A: diacylglycerol acyltransferase that functions in the formation of triglycerides. Lack of mdy leads to female sterility and impaired fat metabolism in larvae and adults.
    
 
 0.867
CG32803
Uncharacterized protein, isoform C.
      
 0.857
ReepA
Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress.
      
 0.845
Gpat4
Glycerol-3-phosphate acyltransferase 4 (Gpat4) encodes a de novo synthase of lysophosphatidic acid.
   
  
 0.825
spas
Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.
   
 
 0.770
CG42853
Reticulon-like protein.
   
  
 0.762
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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