STRINGSTRING
Seipin protein (fruit fly) - STRING interaction network
Seipin in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SeipinSeipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis (370 aa)    
Predicted Functional Partners:
CG11162
C-4 methylsterol oxidase activity (278 aa)
     
 
  0.625
fa2h
Fatty acid 2-hydroylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids (355 aa)
       
 
  0.608
CG12001
CG12001 gene product from transcript CG12001-RA; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both syn [...] (553 aa)
           
  0.506
CG3812
1-acylglycerol-3-phosphate O-acyltransferase activity (343 aa)
           
  0.504
Aats-gly
Glycyl-tRNA synthetase (765 aa)
           
  0.479
fu12
Fu12 (271 aa)
     
   
  0.434
CG4753
1-acylglycerol-3-phosphate O-acyltransferase activity (380 aa)
     
   
  0.419
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: medium (53%) [HD]