STRINGSTRING
w protein (fruit fly) - STRING interaction network
"w" - White in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
wWhite; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules (687 aa)    
Predicted Functional Partners:
su(Hw)
Suppressor of Hairy wing; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into i [...] (941 aa)
     
 
  0.920
bw
Brown; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Brown and white dimerize for the transport of guanine (675 aa)
       
0.916
Trl
Trithorax-like (623 aa)
       
 
  0.848
z
Zeste; Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter (605 aa)
       
 
  0.848
trx
Trithorax; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo (3726 aa)
       
 
  0.840
CG1703
ATPase activity, coupled to transmembrane movement of substances; transporter activity (901 aa)
     
  0.817
pho
Pleiohomeotic; Polycomb group (PcG) protein that binds to the 5’- CNGCCATNNNNG-3’ sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not suffi [...] (520 aa)
     
 
  0.809
CG9330
ATPase activity, coupled to transmembrane movement of substances; transporter activity (708 aa)
     
  0.807
Su(var)205
Suppressor of variegation 205; Structural component of heterochromatin, involved in gene repression and the modification of position-effect- variegation. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression (206 aa)
       
 
  0.806
dwg
Deformed wings (592 aa)
     
 
  0.786
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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