• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
w protein (fruit fly) - STRING interaction network
"w" - Protein white in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wProtein white; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. White dimerize with brown for the transport of guanine. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules (687 aa)    
Predicted Functional Partners:
pix
Pixie, isoform A; Pixie encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth (611 aa)
           
  0.859
CG9281
CG9281, isoform B; ATPase activity, coupled to transmembrane movement of substances; ATP binding; transporter activity (611 aa)
       
 
  0.841
st
Protein scarlet; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules (666 aa)
   
 
 
0.817
su(Hw)
Protein suppressor of hairy wing; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fibe [...] (941 aa)
     
 
  0.814
Psc
Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-118’, rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] (1601 aa)
       
 
  0.794
bw
The Brown (Bw) protein is a member of the traffic ATPase (or ABC) family of membrane transporters. It is believed to heterodimerize with the w protein. Bw and w are necessary to import guanine, a precursor for the red pteridine pigments, into pigment cells of the eyes, Malpighian tubules and testis sheath (675 aa)
       
   
0.791
CG2316
CG2316, isoform A; ATPase activity, coupled to transmembrane movement of substances; ATP binding; transporter activity. It is involved in the biological process described with- transmembrane transport (730 aa)
     
   
  0.781
trx
Histone-lysine N-methyltransferase trithorax; Histone methyltransferase that methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo (3726 aa)
     
 
  0.751
AttB
Attacin-B is an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria (218 aa)
           
  0.750
MRP
Multidrug-Resistance like protein 1, isoform A; ATPase activity, coupled to transmembrane movement of substances; ATP binding; ATPase activity, coupled to movement of substances; xenobiotic-transporting ATPase activity. It is involved in the biological process described with- response to methotrexate; transmembrane transport (1549 aa)
   
 
  0.723
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (8%) [HD]