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crm protein (fruit fly) - STRING interaction network
"crm" - Cramped in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
crmCramped; Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV) (982 aa)    
Predicted Functional Partners:
BEAF-32
Boundary element-associated factor of 32kD (283 aa)
       
      0.704
z
Zeste; Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter (605 aa)
     
   
  0.501
CG15432
IP21509p (118 aa)
           
  0.482
CG31924
Hydrolase activity (236 aa)
           
  0.482
CG5565
Hydrolase activity (240 aa)
           
  0.482
Gs1l
GS1-like; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation (231 aa)
           
  0.482
egh
Egghead; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system (457 aa)
           
  0.472
wapl
Wings apart-like; Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation (1741 aa)
     
        0.472
Der-2
Derlin-2; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins (261 aa)
           
  0.426
Trap1
Trap1 (691 aa)
           
  0.422
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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