STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ng4Protein new-glue 4. (57 aa)    
Predicted Functional Partners:
CG12290
Orphan GPCR CG12290; Alpha1-adrenergic receptor activity; G protein-coupled receptor activity.
      
 0.659
mthl5
Methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis.
      
 0.658
Pig1
Pre-intermoult gene 1 protein.
   
  
 0.538
Sgs4
Salivary glue protein Sgs-4; It is involved in the biological process described with: puparial adhesion.
      
 0.533
Pkc98E
Protein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn.
      
 0.449
RpS5b
40S ribosomal protein S5b; rRNA binding; structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the universal ribosomal protein uS7 family.
      
 0.430
Ggamma1
Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation.
      
 0.430
5-HT1B
5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7.
      
 0.430
Octbeta2R
Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R.
      
 0.430
RpS5a
Ribosomal protein S5a (RpS5a) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS7 family.
      
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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