| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Diap2 | Ilp1 | FBpp0086431 | FBpp0076057 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | 0.911 |
| Diap2 | Ilp2 | FBpp0086431 | FBpp0076058 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.913 |
| Diap2 | Ilp3 | FBpp0086431 | FBpp0076102 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. | 0.916 |
| Diap2 | Ilp4 | FBpp0086431 | FBpp0076101 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family. | 0.835 |
| Diap2 | Ilp5 | FBpp0086431 | FBpp0422627 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. | 0.915 |
| Diap2 | Ilp6 | FBpp0086431 | FBpp0070390 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. | 0.897 |
| Diap2 | Ilp7 | FBpp0086431 | FBpp0070552 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth. | 0.835 |
| Diap2 | Ilp8 | FBpp0086431 | FBpp0288660 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing. | 0.676 |
| Diap2 | InR | FBpp0086431 | FBpp0083519 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | 0.960 |
| Ilp1 | Diap2 | FBpp0076057 | FBpp0086431 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | 0.911 |
| Ilp1 | Ilp2 | FBpp0076057 | FBpp0076058 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.993 |
| Ilp1 | Ilp3 | FBpp0076057 | FBpp0076102 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. | 0.990 |
| Ilp1 | Ilp4 | FBpp0076057 | FBpp0076101 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family. | 0.924 |
| Ilp1 | Ilp5 | FBpp0076057 | FBpp0422627 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. | 0.990 |
| Ilp1 | Ilp6 | FBpp0076057 | FBpp0070390 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. | 0.990 |
| Ilp1 | Ilp7 | FBpp0076057 | FBpp0070552 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth. | 0.990 |
| Ilp1 | Ilp8 | FBpp0076057 | FBpp0288660 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing. | 0.839 |
| Ilp1 | InR | FBpp0076057 | FBpp0083519 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. | 0.993 |
| Ilp1 | Lgr3 | FBpp0076057 | FBpp0084273 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. | Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) encodes a protein activated by the relaxin-like hormone encoded by Ilp8, which coordinates organ growth. | 0.444 |
| Ilp2 | Diap2 | FBpp0076058 | FBpp0086431 | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | 0.913 |