STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
brnBeta-1,3-galactosyltransferase brn; Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal- ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation. (325 aa)    
Predicted Functional Partners:
egh
Beta-1,4-mannosyltransferase egh; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system; Belongs to the glycosyltransferase 2 family.
      
 0.896
beta4GalNAcTB
beta1,4-N-acetylgalactosaminyltransferase B (beta4GalNAcTB) encodes a Golgi glycosyltransferase that transfers N-acetylgalactosamine to N-acetylglucosamine residues of glycosphingolipids.
   
  
 0.858
Hml
Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction.
   
 
  0.750
Ndg
Nidogen; Cell adhesion glycoprotein which is widely distributed in basement membranes. Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks. Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity. Not involved in assembly of the embryonic basement membrane.
     
  0.750
beta4GalNAcTA
beta1,4-N-acetylgalactosaminyltransferase A (beta4GalNAcTA) encodes a acetylgalactosaminyltransferase involved in glycolipid biosynthesis. It contributes to the development of the neuromuscular junction.
   
  
 0.727
beta-Man
Beta-Mannosidase, isoform A; Beta-mannosidase activity. It is involved in the biological process described with: glycoprotein catabolic process.
      
 0.627
alpha4GT1
Alpha1,4-galactosyltransferase 1; Transferase activity, transferring hexosyl groups; acetylgalactosaminyltransferase activity; alpha-1,4-N-acetylgalactosaminyltransferase activity. It is involved in the biological process described with: negative regulation of apoptotic process; glycosphingolipid biosynthetic process; glycolipid biosynthetic process.
   
  
 0.514
alpha4GT2
Alpha1,4-galactosyltransferase 2; Transferase activity, transferring hexosyl groups; alpha-1,4-N-acetylgalactosaminyltransferase activity. It is involved in the biological process described with: glycosphingolipid biosynthetic process.
      
 0.513
obe
Obelus (obe) encodes a Ski2-family helicase that regulates alternative mRNA splicing of crb. It is required for cell polarity and adherens junction organization.
      
 0.491
CG34384
Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
      
 0.489
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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