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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
Score
CG3009RH14732p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process. (342 aa)    
Predicted Functional Partners:
GIIIspla2
Phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
  
  
 
0.912
sPLA2
Secretory phospholipase A2, isoform A; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
  
  
 
0.911
CG30503
RH50933p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
  
  
 
0.911
iPLA2-VIA
Calcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome.
     
 0.910
Pss
LD10327p; Phosphotransferase activity, for other substituted phosphate groups; L-serine-phosphatidylethanolamine phosphatidyltransferase activity. It is involved in the biological process described with: phosphatidylserine biosynthetic process.
     
 0.906
CG14507
Calcium ion binding; phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process; lipid catabolic process.
     
 0.906
CG7582
GH04784p; Alkenylglycerophosphoethanolamine hydrolase activity; alkenylglycerophosphocholine hydrolase activity.
   
 
  0.903
sws
Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family.
     
  0.900
Paf-AHalpha
Platelet-activating factor acetylhydrolase IB subunit beta homolog.
     
  0.900
SMSr
Sphingomyelin synthase-related 1; Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory [...]
     
  0.900
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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