STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
ctpDynein light chain 1, cytoplasmic; Cut up (ctp) encodes the 8 kDa (LC8/DLC1) subunit of the cytoplasmic Dynein, as well as the Myosin V. It homodimerizes and binds to a variety of proteins. It is involved in both dynein-dependent and independent functions such as cell viability, axonal guidance, spermatid growth and individualization, and regulation of spermatogonial divisions; Belongs to the dynein light chain family. (267 aa)    
Predicted Functional Partners:
sw
Cytoplasmic dynein 1 intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
    
 0.999
Dlc90F
Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex.
   
 0.998
swa
Protein swallow; Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.
    
 
 0.981
Sdic1
Sperm-specific dynein intermediate chain 1, isoform A; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; microtubule-based movement.
    
 0.980
Sdic2
Sperm-specific dynein intermediate chain 2, isoform A; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; microtubule-based movement.
    
 0.977
Sdic3
Sperm-specific dynein intermediate chain 3, isoform E; It is involved in the biological process described with: microtubule-based movement.
    
 0.977
SdicC
Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: microtubule-based movement; transport along microtubule; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed.
    
 0.977
SdicB
It is involved in the biological process described with: microtubule-based movement.
    
 0.977
SdicA
It is involved in the biological process described with: microtubule-based movement.
    
 0.977
Dhc64C
Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis.
    
 0.954
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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