node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ance | Ide | FBpp0080130 | FBpp0271781 | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.669 |
Ance | Nep1 | FBpp0080130 | FBpp0310420 | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.842 |
Ance-2 | Ide | FBpp0080131 | FBpp0271781 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.672 |
Ance-2 | Nep1 | FBpp0080131 | FBpp0310420 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.841 |
Ance-3 | Ide | FBpp0310234 | FBpp0271781 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.672 |
Ance-3 | Nep1 | FBpp0310234 | FBpp0310420 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.844 |
Ance-4 | Ide | FBpp0087745 | FBpp0271781 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.670 |
Ance-4 | Nep1 | FBpp0087745 | FBpp0310420 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.840 |
Ance-5 | Ide | FBpp0072325 | FBpp0271781 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.672 |
Ance-5 | Nep1 | FBpp0072325 | FBpp0310420 | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.840 |
Bace | Ide | FBpp0310072 | FBpp0271781 | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | 0.410 |
Bace | Nct | FBpp0310072 | FBpp0306637 | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.662 |
Bace | Nep1 | FBpp0310072 | FBpp0310420 | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. | Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family. | 0.542 |
Bace | Psn | FBpp0310072 | FBpp0077850 | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.713 |
Bace | pen-2 | FBpp0310072 | FBpp0309291 | Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.579 |
Ide | Ance | FBpp0271781 | FBpp0080130 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. | 0.669 |
Ide | Ance-2 | FBpp0271781 | FBpp0080131 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.672 |
Ide | Ance-3 | FBpp0271781 | FBpp0310234 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.672 |
Ide | Ance-4 | FBpp0271781 | FBpp0087745 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.670 |
Ide | Ance-5 | FBpp0271781 | FBpp0072325 | Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. | Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. | 0.672 |