STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vanin-likeVanin-like protein 1; Probable hydrolase; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. (558 aa)    
Predicted Functional Partners:
Smvt
Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
  
 0.848
LKRSDH
Lysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway.
  
 
  0.816
PCB
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
      
 0.640
sced
Scrambled, isoform A; Scrambled (sced) encodes a protein that localizes to the mitotic furrows and centrosomes. It is involved in actin reorganization during cell cycle and the assembly of pseudocleavage furrows in syncytial embryos.
    
   0.564
Muc68E
Mucin 68E; Extracellular matrix structural constituent; chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
  
 0.553
Est-Q
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
   
  
 0.545
Mipp1
Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation [...]
   
  
 0.534
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
   
  
 0.518
Tpc1
Thiamine pyrophosphate carrier protein 1 (Tpc1) encodes an important protein for mitochondrial metabolism located at the inner mitochondrial membrane. Its main role is to import thiamine pyrophosphate (ThPP) into mitochondria. ThPP is an essential coenzyme for the E1 components of pyruvate dehydrogenase and oxoglutarate dehydrogenase, which are located in the mitochondrial matrix.
      
 0.495
Amnionless
Protein amnionless; Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Cubn.
      
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.