STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
schlankSchlank, isoform A; Schlank is a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators (400 aa)    
Predicted Functional Partners:
Putative neutral sphingomyelinase; Sphingomyelin phosphodiesterase activity. It is involved in the biological process described with: sphingomyelin metabolic process
LD07939p; Oxidoreductase activity. It is involved in the biological process described with: metabolic process
D-erythro-sphingosine kinase activity; diacylglycerol kinase activity; NAD+ kinase activity. It is involved in the biological process described with: oviposition; sphingolipid metabolic process; flight behavior; protein kinase C-activating G-protein coupled receptor signaling pathway; phosphorylation
Ceramide kinase (Cerk) catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. Cerk is also a component of WntD signaling and mediates primordial germ cell migration
Sphingolipid delta-4 desaturase activity; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: spermatogenesis; sphingolipid biosynthetic process; spindle assembly involved in male meiosis
Sphingosine kinase 1(Sk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. Sk1 regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair
Glucosylceramide synthase (GlcT-1) catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. GlcT-1 regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development
Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself ma [...]
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide
NAD-dependent histone deacetylase Sir2; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin- mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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