STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
schlankSchlank, isoform A; Schlank is a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators (400 aa)    
Predicted Functional Partners:
CG12034
Putative neutral sphingomyelinase; Sphingomyelin phosphodiesterase activity. It is involved in the biological process described with: sphingomyelin metabolic process
     
 0.984
CG10425
LD07939p; Oxidoreductase activity. It is involved in the biological process described with: metabolic process
   
 
 0.981
Sk2
D-erythro-sphingosine kinase activity; diacylglycerol kinase activity; NAD+ kinase activity. It is involved in the biological process described with: oviposition; sphingolipid metabolic process; flight behavior; protein kinase C-activating G-protein coupled receptor signaling pathway; phosphorylation
   
 
 0.979
Cerk
Ceramide kinase (Cerk) catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. Cerk is also a component of WntD signaling and mediates primordial germ cell migration
   
 
 0.977
ifc
Sphingolipid delta-4 desaturase activity; stearoyl-CoA 9-desaturase activity. It is involved in the biological process described with: spermatogenesis; sphingolipid biosynthetic process; spindle assembly involved in male meiosis
     
 0.977
Sk1
Sphingosine kinase 1(Sk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. Sk1 regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair
   
 
 0.973
GlcT-1
Glucosylceramide synthase (GlcT-1) catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. GlcT-1 regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development
   
 
 0.956
foxo
Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself ma [...]
   
 
 0.954
CG3376
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide
     
 0.946
Sir2
NAD-dependent histone deacetylase Sir2; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin- mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span
   
  
 0.929
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (14%) [HD]