node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDase | CG10425 | FBpp0085011 | FBpp0084241 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | 0.959 |
CDase | Cerk | FBpp0085011 | FBpp0078446 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration. | 0.991 |
CDase | GlcT | FBpp0085011 | FBpp0071669 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development. | 0.969 |
CDase | Sk1 | FBpp0085011 | FBpp0073347 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair. | 0.975 |
CDase | Sk2 | FBpp0085011 | FBpp0072854 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | 0.987 |
CDase | bwa | FBpp0085011 | FBpp0303611 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.995 |
CDase | ifc | FBpp0085011 | FBpp0078810 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Sphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.949 |
CDase | lace | FBpp0085011 | FBpp0080297 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Lace, isoform A; Lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis. | 0.917 |
CDase | nSMase | FBpp0085011 | FBpp0072907 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Putative neutral sphingomyelinase; Sphingomyelin phosphodiesterase activity. It is involved in the biological process described with: sphingomyelin metabolic process. | 0.986 |
CDase | schlank | FBpp0085011 | FBpp0070899 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. | 0.987 |
CG10425 | CDase | FBpp0084241 | FBpp0085011 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition. Belongs to the neutral ceramidase family. | 0.959 |
CG10425 | Cerk | FBpp0084241 | FBpp0078446 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration. | 0.829 |
CG10425 | GlcT | FBpp0084241 | FBpp0071669 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development. | 0.524 |
CG10425 | Sk1 | FBpp0084241 | FBpp0073347 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair. | 0.925 |
CG10425 | Sk2 | FBpp0084241 | FBpp0072854 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | 0.925 |
CG10425 | bwa | FBpp0084241 | FBpp0303611 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.509 |
CG10425 | ifc | FBpp0084241 | FBpp0078810 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Sphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.962 |
CG10425 | lace | FBpp0084241 | FBpp0080297 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Lace, isoform A; Lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis. | 0.986 |
CG10425 | nSMase | FBpp0084241 | FBpp0072907 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Putative neutral sphingomyelinase; Sphingomyelin phosphodiesterase activity. It is involved in the biological process described with: sphingomyelin metabolic process. | 0.408 |
CG10425 | schlank | FBpp0084241 | FBpp0070899 | LD07939p; 3-dehydrosphinganine reductase activity. It is involved in the biological process described with: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process. | Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. | 0.974 |