STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pigsGAS2-like protein pickled eggs; Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons; Belongs to the GAS2 family. (977 aa)    
Predicted Functional Partners:
CG13243
AT09889p.
   
 
 0.716
Alp4
Alkaline phosphatase 4; Important role in neural and renal epithelial function.
      
 0.630
CG17732
Uncharacterized protein.
    
 
 0.570
Smr
Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development.
   
 
 0.562
Nipped-A
Transcription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes.
    
 
 0.538
Ada3
Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes.
    
 
 0.538
mRpS5
Mitochondrial ribosomal protein S5, isoform A; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation; Belongs to the universal ribosomal protein uS5 family.
      
 0.532
Spt3
FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex.
    
 
 0.509
rn
Zinc finger protein rotund; Transcription factor involved in imaginal disks development. Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk. Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment. Also required for the epithelial- mesenchymal transition branch of basolateral junctions signaling. Belongs to the krueppel C2H2-type zinc-finger protein family.
    
 
 0.499
corto
Centrosomal and chromosomal factor; Corto (corto) encodes an Enhancer of Trithorax and Polycomb (ETP) protein that physically interacts with several Polycomb proteins (encoded by Pc, ph-d, ph-p, esc, E(z)) and ETP (encoded by Trl, Dsp1). It also interacts with the product of CycG, with the methylated product of RpL12 (RPL12K3me3), and co-regulates the transcription of genes involved in ribosome biogenesis.
   
  
 0.478
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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