Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sovSmall ovary, isoform A; Nucleic acid binding. (3313 aa)    
Predicted Functional Partners:
Panx
Protein panoramix; Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts. Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing. In the ovaries, forms a complex with n [...]
   
 
 0.966
Su(var)205
Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
    
 
 0.861
ADD1
ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin.
   
 
 0.790
CG1815
GH01331p; Methylated histone binding; lysine-acetylated histone binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
   
 
 0.696
wde
Windei, isoform A; Windei (wde) encodes a chromatin-associated protein that functions as an essential cofactor and binding partner for the methyl transferase encoded by egg. It also binds to the chromosome 4-specific protein encoded by Pof. wde product is required for survival of female germ line cells.
   
 
 0.689
CG4281
GH10944p.
   
  
 0.686
CG30403
Uncharacterized protein; DNA binding.
      
 0.670
tea
Protein telomere ends associated; Protects telomeres from fusion. Likely to function as a component of the MTV complex along with moi and ver. The complex binds single-stranded DNA in a sequence-independent manner and can protect it from DNA degradation.
   
  
 0.633
CG43736
Uncharacterized protein, isoform I.
   
  
 0.624
Su(var)2-10
Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination.
   
 
 0.618
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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