Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bouGEO07593p1; Boudin (bou) encodes a membrane glycoprotein of the Ly6 superfamily that is required for the formation of septate junctions in epithelial tissues. (149 aa)    
Predicted Functional Partners:
cold
Coiled, isoform A; Coiled (cold) encodes a membrane glycoprotein of the Ly6 family that is required for the formation of septate junctions in both epithelial tissues and in sub-perineural glial cells.
   
  
 0.865
crok
GEO12654p1; GPI anchor binding. It is involved in the biological process described with: septate junction assembly; sleep; positive regulation of voltage-gated potassium channel activity; regulation of tube size, open tracheal system; regulation of synaptic transmission, cholinergic.
   
  
 0.796
crim
GEO04224p1; Crimpled (crim) encodes a protein involved in tracheal system development and the localization of septate junction components.
   
  
 0.755
CG8861
Uncharacterized protein, isoform B.
      
 0.748
rtv
Retroactive, isoform A; Retroactive (rtv) encodes a membrane-inserted protein required for chitin organization in the cuticle and the tracheal system.
   
  
 0.710
Nrx-IV
Neurexin-4; Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. Belongs to the neurexin family.
   
  
 0.625
CG1647
Uncharacterized protein, isoform A; Zinc ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
   
  
 0.595
ogre
Innexin inx1; Optic ganglion reduced (ogre) encodes one of the innexin subunits spanning the membrane 4 times. Together with the products of Inx2 and Inx3, it forms homo or hetero oligomers forming gap junctions, which allow the transfer of small solute between cells.
   
  
 0.546
kune
Kune-kune; It is involved in the biological process described with: establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; septate junction assembly.
   
  
 0.542
sinu
Sinuous (sinu) encodes a claudin that contributes to the assembly of septate junctions. It is involved in the development of heart, tracheal tree and the glial blood-brain barrier.
   
  
 0.535
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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