STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
Inx2Innexin inx2; Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst f [...] (367 aa)    
Predicted Functional Partners:
shg
DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...]
   
 
 0.796
Inx3
Innexin 3 (Inx3) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the product of Inx2. Loss of Inx3 leads to the destabilization of the products of ogre, Inx2 and shg at the plasma membrane, suggesting that these four proteins form a complex.
  
 
0.742
ogre
Innexin inx1; Optic ganglion reduced (ogre) encodes one of the innexin subunits spanning the membrane 4 times. Together with the products of Inx2 and Inx3, it forms homo or hetero oligomers forming gap junctions, which allow the transfer of small solute between cells.
  
  
0.607
CG4942
LD38503p; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; protein insertion into membrane; mitochondrial cytochrome c oxidase assembly.
    
 
 0.535
dy
LP20007p; Dusky (dy) encodes a membrane-anchored protein of the zona pellucida domain protein familiy. Along with the homologous gene m, it regulates epidermal cell size/shape changes during wing morphogenesis. It also functions to remodel epidermal cell shape during embryonic and later developmental stages, through interactions with the extracellular matrix.
  
 
   0.522
pio
Piopio, isoform B; Piopio (pio) encodes a zona pellucida (ZP) domain protein that mediates the adhesion of the apical epithelial surface and the overlying apical extracellular matrix.
  
   0.515
zpg
Innexin inx4; Structural component of the gap junctions in germline cells. Required for differentiation and survival of germline cysts in females and of spermatogonia in males; gap junctional communication between spermatogonia and somatic cyst cells may be required for normal differentiation and survival of spermatogonia. Belongs to the pannexin family.
  
   
0.510
MEP-1
MEP-1, isoform A; MEP-1 (MEP-1) encodes a zinc finger protein that associates with the ATP-dependent nucleosome remodeler encoded by Mi-2. It cooperates with the product of Mi-2 in the repression of cell type-specific genes.
  
     0.507
CG3655
Glycosyltransferase family 92 protein; UDP-galactosyltransferase activity. It is involved in the biological process described with: N-glycan processing; Belongs to the glycosyltransferase 92 family.
  
    0.504
CG10591
Uncharacterized protein.
    
 
 0.497
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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